SLC23A1,2 cotransports AscH-, 2Na+ from extracellular region to cytosol
AscH- + 2 Na+ → AscH- + 2 Na+
- Reactome
- R-HSA-198870
- Compartment
- plasma membrane
- Rhea
- RHEA:69883
Inputs
- AscH-CHEBI:38290, C6H7O6, extracellular region
- 2 Na+CHEBI:29101, Na, extracellular region
Outputs
- AscH-CHEBI:38290, C6H7O6, cytosol
- 2 Na+CHEBI:29101, Na, cytosol
Catalysed by
- L-ascorbic acid transmembrane transporter activity of SLC23A1,2 [plasma membrane]
Literature
- Vitamin C transport systems of mammalian cells Mol Membr Biol, 2001
- Human placental sodium-dependent vitamin C transporter (SVCT2): molecular cloning and transport function Biochem Biophys Res Commun, 1999
- Cloning and functional characterization of the human sodium-dependent vitamin C transporters hSVCT1 and hSVCT2 FEBS Lett, 1999
- Human Na+-dependent vitamin C transporter 1 (hSVCT1): primary structure, functional characteristics and evidence for a non-functional splice variant Biochim Biophys Acta, 1999