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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

CYB5A:heme reduces Asc.- to AscH-

Asc.- + CYB5A:heme → AscH- + CYB5A:ferriheme

Reactome: R-HSA-198845
Compartment: cytosol · mitochondrial outer membrane
Rhea: None recorded

Inputs

Asc.-CHEBI:59513, C6H6O6, cytosol
CYB5A:hemeR-HSA-198808, mitochondrial outer membrane

Outputs

AscH-CHEBI:38290, C6H7O6, cytosol
CYB5A:ferrihemeR-HSA-198772, mitochondrial outer membrane

Catalysed by

alcohol dehydrogenase (NADP+) activity of CYB5A:heme [mitochondrial outer membrane]EC 1.1.1.2

Literature

A novel point mutation in a 3' splice site of the NADH-cytochrome b5 reductase gene results in immunologically undetectable enzyme and impaired NADH-dependent ascorbate regeneration in cultured fibroblasts of a patient with type II hereditary methemoglobinemia Am J Hum Genet, 1995