CYB5R3:FAD reduces CYB5A:ferriheme to CYB5A:heme
CYB5A:ferriheme + NADH + H+ → CYB5A:heme + NAD+
- Reactome
- R-HSA-198824
- Compartment
- cytosol · mitochondrial outer membrane
- Rhea
- None recorded
Inputs
- CYB5A:ferrihemeR-HSA-198772, mitochondrial outer membrane
- NADHCHEBI:57945, C21H27N7O14P2, cytosol
- H+CHEBI:15378, H, cytosol
Outputs
- CYB5A:hemeR-HSA-198808, mitochondrial outer membrane
- NAD+CHEBI:57540, C21H26N7O14P2, cytosol
Catalysed by
- cytochrome-b5 reductase activity, acting on NAD(P)H of CYB5R3:FAD [mitochondrial outer membrane]EC 1.6.2.2
Literature
- NADH-cytochrome b5 reductase and cytochrome b5 isoforms as models for the study of post-translational targeting to the endoplasmic reticulum FEBS Lett, 1993
- A novel point mutation in a 3' splice site of the NADH-cytochrome b5 reductase gene results in immunologically undetectable enzyme and impaired NADH-dependent ascorbate regeneration in cultured fibroblasts of a patient with type II hereditary methemoglobinemia Am J Hum Genet, 1995