Loading the map…

Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

GSTO dimers reduce DeHA to AscH-

DeHA + 2 GSH → AscH- + GSSG

Reactome: R-HSA-198813
Compartment: cytosol
Rhea: RHEA:24425

Inputs

DeHACHEBI:58539, C6H5O6, cytosol
2 GSHCHEBI:57925, C10H16N3O6S, cytosol

Outputs

AscH-CHEBI:38290, C6H7O6, cytosol
GSSGCHEBI:58297, C20H30N6O12S2, cytosol

Catalysed by

glutathione dehydrogenase (ascorbate) activity of GSTO dimers [cytosol]EC 1.8.5.1

GSTO dimers reduce DeHA to AscH-

Inputs

Outputs

Catalysed by

Literature