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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

NADSYN1 hexamer amidates NAAD to NAD+

NAAD + ATP + H2O + L-Gln → NAD+ + AMP + PPi + L-Glu + H+

Reactome: R-HSA-197271
Compartment: cytosol
Rhea: RHEA:24385

Inputs

NAADCHEBI:58437, C21H24N6O15P2, cytosol
ATPCHEBI:30616, C10H12N5O13P3, cytosol
H2OCHEBI:15377, H2O, cytosol
L-GlnCHEBI:58359, C5H10N2O3, cytosol

Outputs

NAD+CHEBI:57540, C21H26N7O14P2, cytosol
AMPCHEBI:456215, C10H12N5O7P, cytosol
PPiCHEBI:33019, HO7P2, cytosol
L-GluCHEBI:29985, C5H8NO4, cytosol
H+CHEBI:15378, H, cytosol

Catalysed by

NAD+ synthase (glutamine-hydrolyzing) activity of NADSYN1 hexamer [cytosol]EC 6.3.5.1

Literature

Molecular identification of human glutamine- and ammonia-dependent NAD synthetases. Carbon-nitrogen hydrolase domain confers glutamine dependency. J Biol Chem, 2003