NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD
ATP + NAMN + H+ → NAAD + PPi
- Reactome
- R-HSA-197235
- Compartment
- cytosol · Golgi membrane
- Rhea
- RHEA:22861
Inputs
- ATPCHEBI:30616, C10H12N5O13P3, cytosol
- NAMNCHEBI:57502, C11H12NO9P, cytosol
- H+CHEBI:15378, H, cytosol
Outputs
- NAADCHEBI:58437, C21H24N6O15P2, cytosol
- PPiCHEBI:33019, HO7P2, cytosol
Catalysed by
- nicotinate-nucleotide adenylyltransferase activity of NMNAT2:Mg2+ [Golgi membrane]EC 2.7.7.18
Literature
- Characterization of human brain nicotinamide 5'-mononucleotide adenylyltransferase-2 and expression in human pancreas Biochem J, 2004
- Identification of a novel human nicotinamide mononucleotide adenylyltransferase Biochem Biophys Res Commun, 2002
- Subcellular compartmentation and differential catalytic properties of the three human nicotinamide mononucleotide adenylyltransferase isoforms J Biol Chem, 2005
- Initial-rate kinetics of human NMN-adenylyltransferases: substrate and metal ion specificity, inhibition by products and multisubstrate analogues, and isozyme contributions to NAD+ biosynthesis Biochemistry, 2007