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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+

NAD+ + ATP → NADP+ + ADP + H+

Reactome: R-HSA-197198
Compartment: cytosol
Rhea: RHEA:18630

Inputs

NAD+CHEBI:57540, C21H26N7O14P2, cytosol
ATPCHEBI:30616, C10H12N5O13P3, cytosol

Outputs

NADP+CHEBI:58349, C21H25N7O17P3, cytosol
ADPCHEBI:456216, C10H12N5O10P2, cytosol
H+CHEBI:15378, H, cytosol

Catalysed by

NAD+ kinase activity of NADK:Zn2+ tetramer [cytosol]EC 2.7.1.23

Literature

Structural and functional characterization of human NAD kinase Biochem Biophys Res Commun, 2001