NAPRT1 dimer transfers PRIB to NCA to form NAMN
NCA + PRPP + ATP + H2O → PPi + NAMN + ADP + Pi
- Reactome
- R-HSA-197186
- Compartment
- cytosol
- Rhea
- RHEA:36164
Inputs
- NCACHEBI:32544, C6H4NO2, cytosol
- PRPPCHEBI:58017, C5H8O14P3, cytosol
- ATPCHEBI:30616, C10H12N5O13P3, cytosol
- H2OCHEBI:15377, H2O, cytosol
Outputs
- PPiCHEBI:33019, HO7P2, cytosol
- NAMNCHEBI:57502, C11H12NO9P, cytosol
- ADPCHEBI:456216, C10H12N5O10P2, cytosol
- PiCHEBI:43474, HO4P, cytosol
Catalysed by
- nicotinate phosphoribosyltransferase activity of NAPRT1 dimer [cytosol]EC 6.3.4.21
Literature
- Nicotinate phosphoribosyltransferase of human erythrocytes. Purification and properties. J Biol Chem, 1973
- Biosynthesis of diphosphopyridine nucleotide. II. Enzymatic aspects. J Biol Chem, 1958
- Elevation of cellular NAD levels by nicotinic acid and involvement of nicotinic acid phosphoribosyltransferase in human cells J Biol Chem, 2007