Chondroitin polymerase complex transfers GlcA to CS chain
UDP-GlcA + chondroitin(1)-core proteins → UDP + chondroitin(2)-core proteins + H+
- Reactome
- R-HSA-1971491
- Compartment
- Golgi membrane · Golgi lumen
- Rhea
- None recorded
Inputs
- UDP-GlcACHEBI:58052, C15H19N2O18P2, Golgi lumen
- chondroitin(1)-core proteinsR-HSA-2064172, Golgi lumen
Outputs
- UDPCHEBI:58223, C9H11N2O12P2, Golgi lumen
- chondroitin(2)-core proteinsR-HSA-2064050, Golgi lumen
- H+CHEBI:15378, H, Golgi lumen
Catalysed by
- N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity of Chondroitin polymerase complex [Golgi membrane]EC 2.4.1.226
Literature
- Molecular cloning and expression of a human chondroitin synthase J Biol Chem, 2001
- Chondroitin sulfate synthase-2. Molecular cloning and characterization of a novel human glycosyltransferase homologous to chondroitin sulfate glucuronyltransferase, which has dual enzymatic activities J Biol Chem, 2003
- Chondroitin sulfate synthase-3. Molecular cloning and characterization J Biol Chem, 2003
- Identification of chondroitin sulfate glucuronyltransferase as chondroitin synthase-3 involved in chondroitin polymerization: chondroitin polymerization is achieved by multiple enzyme complexes consisting of chondroitin synthase family members J Biol Chem, 2008
- Molecular cloning and characterization of a novel chondroitin sulfate glucuronyltransferase that transfers glucuronic acid to N-acetylgalactosamine J Biol Chem, 2002
- Loss of CHSY1, a secreted FRINGE enzyme, causes syndromic brachydactyly in humans via increased NOTCH signaling Am J Hum Genet, 2010