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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

Chondroitin polymerase complex transfers GalNAc to CS chain

chondroitin(2)-core proteins + UDP-GalNAc → UDP + chondroitin(3)-core proteins + H+

Reactome: R-HSA-1971487
Compartment: Golgi membrane · Golgi lumen
Rhea: None recorded

Inputs

chondroitin(2)-core proteinsR-HSA-2064050, Golgi lumen
UDP-GalNAcCHEBI:57847, C17H25N3O17P2, Golgi lumen

Outputs

UDPCHEBI:58223, C9H11N2O12P2, Golgi lumen
chondroitin(3)-core proteinsR-HSA-2064075, Golgi lumen
H+CHEBI:15378, H, Golgi lumen

Catalysed by

glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity of Chondroitin polymerase complex [Golgi membrane]EC 2.4.1.175

Literature

Chondroitin sulfate synthase-2. Molecular cloning and characterization of a novel human glycosyltransferase homologous to chondroitin sulfate glucuronyltransferase, which has dual enzymatic activities J Biol Chem, 2003
Chondroitin sulfate synthase-3. Molecular cloning and characterization J Biol Chem, 2003
Molecular cloning and expression of a human chondroitin synthase J Biol Chem, 2001
Loss of CHSY1, a secreted FRINGE enzyme, causes syndromic brachydactyly in humans via increased NOTCH signaling Am J Hum Genet, 2010
Temtamy preaxial brachydactyly syndrome is caused by loss-of-function mutations in chondroitin synthase 1, a potential target of BMP signaling Am J Hum Genet, 2010
Biosynthesis and function of chondroitin sulfate Biochim Biophys Acta, 2013