CHST11,12,13,9 transfer sulfate to (4-)GalNAc
chondroitin(3)-core proteins + PAPS → C4S-PG + PAP + H+
- Reactome
- R-HSA-1971483
- Compartment
- Golgi membrane · Golgi lumen
- Rhea
- RHEA:16102
Inputs
- chondroitin(3)-core proteinsR-HSA-2064075, Golgi lumen
- PAPSCHEBI:58339, C10H11N5O13P2S, Golgi lumen
Outputs
- C4S-PGR-HSA-2064226, Golgi lumen
- PAPCHEBI:58343, C10H11N5O10P2, Golgi lumen
- H+CHEBI:15378, H, Golgi lumen
Catalysed by
- chondroitin 4-sulfotransferase activity of CHST9,11,12,13 [Golgi membrane]EC 2.8.2.5
Literature
- Molecular cloning and expression of an N-acetylgalactosamine-4-O-sulfotransferase that transfers sulfate to terminal and non-terminal beta 1,4-linked N-acetylgalactosamine J Biol Chem, 2001
- Molecular cloning, expression, and chromosomal mapping of human chondroitin 4-sulfotransferase, whose expression pattern in human tissues is different from that of chondroitin 6-sulfotransferase J Biochem, 2000
- Molecular cloning and expression of two distinct human chondroitin 4-O-sulfotransferases that belong to the HNK-1 sulfotransferase gene family J Biol Chem, 2000
- Molecular cloning and characterization of chondroitin-4-O-sulfotransferase-3. A novel member of the HNK-1 family of sulfotransferases J Biol Chem, 2002
- Homozygous CHST11 mutation in chondrodysplasia, brachydactyly, overriding digits, clino-symphalangism and synpolydactyly J Med Genet, 2018