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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

FLAD1 phosphorylates FMN

FMN + ATP + H+ → FAD + PPi

Reactome: R-HSA-196929
Compartment: cytosol
Rhea: RHEA:17238

Inputs

FMNCHEBI:58210, C17H18N4O9P, cytosol
ATPCHEBI:30616, C10H12N5O13P3, cytosol
H+CHEBI:15378, H, cytosol

Outputs

FADCHEBI:57692, C27H30N9O15P2, cytosol
PPiCHEBI:33019, HO7P2, cytosol

Catalysed by

FMN adenylyltransferase activity of FLAD1 [cytosol]EC 2.7.7.2; UniProt Q8NFF5

Literature

Over-expression in Escherichia coli and characterization of two recombinant isoforms of human FAD synthetase Biochem Biophys Res Commun, 2006