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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

PANK2 phosphorylates PanK

PanK + ATP → PPanK + ADP + H+

Reactome: R-HSA-196857
Compartment: cytosol · mitochondrial intermembrane space
Rhea: RHEA:16374

Inputs

PanKCHEBI:29032, C9H16NO5, cytosol
ATPCHEBI:30616, C10H12N5O13P3, cytosol

Outputs

PPanKCHEBI:10986, C9H15NO8P, cytosol
ADPCHEBI:456216, C10H12N5O10P2, cytosol
H+CHEBI:15378, H, cytosol

Catalysed by

pantothenate kinase activity of PANK2(141-570) [mitochondrial intermembrane space]EC 2.7.1.33; UniProt Q9BZ23

Literature

An isoform of hPANK2, deficient in pantothenate kinase-associated neurodegeneration, localizes to mitochondria Hum Mol Genet, 2003
Mitochondrial localization of human PANK2 and hypotheses of secondary iron accumulation in pantothenate kinase-associated neurodegeneration Ann N Y Acad Sci, 2004
Activation of human mitochondrial pantothenate kinase 2 by palmitoylcarnitine Proc Natl Acad Sci U S A, 2007
Feedback regulation of murine pantothenate kinase 3 by coenzyme A and coenzyme A thioesters J Biol Chem, 2005
Biochemical properties of human pantothenate kinase 2 isoforms and mutations linked to pantothenate kinase-associated neurodegeneration J Biol Chem, 2006
A novel pantothenate kinase gene (PANK2) is defective in Hallervorden-Spatz syndrome Nat Genet, 2001