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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

2xTPK1:Mg2+ phosphorylates THMN

THMN + ATP → ThDP + AMP

Reactome: R-HSA-196761
Compartment: cytosol
Rhea: RHEA:11577

Inputs

THMNCHEBI:18385, C12H17N4OS, cytosol
ATPCHEBI:30616, C10H12N5O13P3, cytosol

Outputs

ThDPCHEBI:58937, C12H16N4O7P2S, cytosol
AMPCHEBI:456215, C10H12N5O7P, cytosol

Catalysed by

thiamine diphosphokinase activity of 2xTPK1:Mg2+ [cytosol]EC 2.7.6.2

Literature

Isolation and characterization of a human thiamine pyrophosphokinase cDNA Biochim Biophys Acta, 2001
Molecular cloning of human thiamin pyrophosphokinase Biochim Biophys Acta, 2001