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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

2xPPCS ligates PPanK with Cys

PPanK + L-Cys + ATP → PPC + AMP + PPi + H+

Reactome: R-HSA-196753
Compartment: cytosol
Rhea: RHEA:25157

Inputs

PPanKCHEBI:10986, C9H15NO8P, cytosol
L-CysCHEBI:35235, C3H7NO2S, cytosol
ATPCHEBI:30616, C10H12N5O13P3, cytosol

Outputs

PPCCHEBI:59458, C12H20N2O9PS, cytosol
AMPCHEBI:456215, C10H12N5O7P, cytosol
PPiCHEBI:33019, HO7P2, cytosol
H+CHEBI:15378, H, cytosol

Catalysed by

phosphopantothenate--cysteine ligase activity of 2xPPCS [cytosol]EC 6.3.2.5

Literature

Complete reconstitution of the human coenzyme A biosynthetic pathway via comparative genomics J Biol Chem, 2002
Structure of human phosphopantothenoylcysteine synthetase at 2.3 A resolution. Structure, 2003