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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

FECH binds Fe2+ to PRIN9 to form heme

PRIN9 + Fe2+ → 2 H+ + heme b

Reactome: R-HSA-189465
Compartment: mitochondrial matrix
Rhea: None recorded

Inputs

PRIN9CHEBI:57306, C34H32N4O4, mitochondrial matrix
Fe2+CHEBI:29033, Fe, mitochondrial matrix

Outputs

2 H+CHEBI:15378, H, mitochondrial matrix
heme bCHEBI:26355, C34H32FeN4O4, mitochondrial inner membrane

Catalysed by

protoporphyrin ferrochelatase activity of 2x(FECH:2Fe-2S cluster) [mitochondrial inner membrane]EC 4.98.1.1

Literature

The 2.0 A structure of human ferrochelatase, the terminal enzyme of heme biosynthesis. Nat Struct Biol, 2001