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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

ALAS condenses SUCC-CoA and Gly to form dALA

SUCC-CoA + Gly + H+ → dALA + CoA-SH + CO2

Reactome: R-HSA-189442
Compartment: mitochondrial matrix
Rhea: RHEA:12922

Inputs

SUCC-CoACHEBI:57292, C25H35N7O19P3S, mitochondrial matrix
GlyCHEBI:57305, C2H5NO2, mitochondrial matrix
H+CHEBI:15378, H, mitochondrial matrix

Outputs

dALACHEBI:356416, C5H9NO3, mitochondrial matrix
CoA-SHCHEBI:57287, C21H32N7O16P3S, mitochondrial matrix
CO2CHEBI:16526, CO2, mitochondrial matrix

Catalysed by

5-aminolevulinate synthase activity of ALAS1,2 [mitochondrial matrix]EC 2.3.1.37

ALAS condenses SUCC-CoA and Gly to form dALA

Inputs

Outputs

Catalysed by

Literature