Skip to content
DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap
Data
100%

Loading the map…

ALAD condenses 2 dALAs to form PBG

2 dALA → PBG + 2 H2O + H+

Reactome
R-HSA-189439
Compartment
cytosol
Rhea
RHEA:24065

Inputs

Outputs

Catalysed by

  • porphobilinogen synthase activity of 8x(ALAD:Zn2+) [cytosol]EC 4.2.1.24

Literature

  1. Mechanistic implications of mutations to the active site lysine of porphobilinogen synthase J Biol Chem, 2001
  2. Novel molecular defects of the delta-aminolevulinate dehydratase gene in a patient with inherited acute hepatic porphyria Hepatology, 2000