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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

PPO oxidises PPGEN9 to PRIN9

PPGEN9 + 3 O2 → PRIN9 + 3 H2O2

Reactome: R-HSA-189423
Compartment: mitochondrial intermembrane space
Rhea: RHEA:25577

Inputs

PPGEN9CHEBI:57307, C34H38N4O4, mitochondrial intermembrane space
3 O2CHEBI:15379, O2, mitochondrial intermembrane space

Outputs

PRIN9CHEBI:57306, C34H32N4O4, mitochondrial intermembrane space
3 H2O2CHEBI:16240, H2O2, mitochondrial intermembrane space

Catalysed by

oxygen-dependent protoporphyrinogen oxidase activity of 2xPPOX:FAD [mitochondrial intermembrane space]EC 1.3.3.4

Literature

Human protoporphyrinogen oxidase: expression, purification, and characterization of the cloned enzyme Protein Sci, 1996
Quantitative structural insight into human variegate porphyria disease J Biol Chem, 2013