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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

Data

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

CPO transforms COPRO3 to PPGEN9

COPRO3 + O2 + H+ → PPGEN9 + 2 CO2 + H2O

Reactome: R-HSA-189421
Compartment: mitochondrial intermembrane space
Rhea: RHEA:18258

Inputs

COPRO3CHEBI:57309, C36H40N4O8, mitochondrial intermembrane space
O2CHEBI:15379, O2, mitochondrial intermembrane space
H+CHEBI:15378, H, mitochondrial intermembrane space

Outputs

PPGEN9CHEBI:57307, C34H38N4O4, mitochondrial intermembrane space
2 CO2CHEBI:16526, CO2, mitochondrial intermembrane space
H2OCHEBI:15377, H2O, mitochondrial intermembrane space

Catalysed by

coproporphyrinogen oxidase activity of 2xCPO [mitochondrial intermembrane space]EC 1.3.3.3

Literature

Kinetic evaluation of human cloned coproporphyrinogen oxidase using a ring isomer of the natural substrate Med Sci Monit, 2005
Evidence that the coproporphyrinogen oxidase activity of rat liver is situated in the intermembrane space of mitochondria Biochem J, 1978
Structural basis of hereditary coproporphyria Proc Natl Acad Sci U S A, 2005
Molecular cloning, sequencing, and functional expression of a cDNA encoding human coproporphyrinogen oxidase Proc Natl Acad Sci U S A, 1994