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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

4 PBGs bind to form HMB

4 PBG + H2O → HMBL + 4 NH4+

Reactome: R-HSA-189406
Compartment: cytosol
Rhea: RHEA:13186

Inputs

4 PBGCHEBI:58126, C10H13N2O4, cytosol
H2OCHEBI:15377, H2O, cytosol

Outputs

HMBLCHEBI:57845, C40H38N4O17, cytosol
4 NH4+CHEBI:28938, H4N, cytosol

Catalysed by

hydroxymethylbilane synthase activity of HMBS:DIPY [cytosol]EC 2.5.1.61

4 PBGs bind to form HMB

Inputs

Outputs

Catalysed by

Literature