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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

HMOX1 dimer, HMOX2 cleave heme

ferroheme + 3 NADPH + 3 O2 → 3 NADP+ + 3 H2O + Fe2+ + CO + BV

Reactome: R-HSA-189398
Compartment: cytosol · endoplasmic reticulum membrane
Rhea: None recorded

Inputs

ferrohemeCHEBI:60344, C34H30FeN4O4, cytosol
3 NADPHCHEBI:57783, C21H26N7O17P3, cytosol
3 O2CHEBI:15379, O2, cytosol

Outputs

3 NADP+CHEBI:58349, C21H25N7O17P3, cytosol
3 H2OCHEBI:15377, H2O, cytosol
Fe2+CHEBI:29033, Fe, cytosol
COCHEBI:17245, CO, cytosol
BVCHEBI:57991, C33H32N4O6, cytosol

Catalysed by

heme oxygenase (decyclizing) activity of HMOX1 dimer, HMOX2 [endoplasmic reticulum membrane]EC 1.14.14.18