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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

BIL translocates from the cytosol to the ER lumen

BIL → BIL

Reactome: R-HSA-189381
Compartment: cytosol · endoplasmic reticulum lumen
Rhea: None recorded

Inputs

BILCHEBI:57977, C33H34N4O6, cytosol

Outputs

BILCHEBI:57977, C33H34N4O6, endoplasmic reticulum lumen

Literature

[Intracellular bilirubin transport and the membrane of the hepatic endoplasmic reticulum: new aspects in the development of transitory bilirubinemia of the newborn] Monatsschr Kinderheilkd, 1972
Extensive protein-protein interactions involving UDP-glucuronosyltransferase (UGT) 2B7 in human liver microsomes Drug Metab. Pharmacokinet., 2014