B3GALT6 transfers Gal to the tetrasaccharide linker
Gal-Xyl-proteins + UDP-Gal → UDP + H+ + Gal-Gal-Xyl-proteins
- Reactome
- R-HSA-1889978
- Compartment
- Golgi membrane · Golgi lumen
- Rhea
- RHEA:11781
Inputs
- Gal-Xyl-proteinsR-HSA-2064058, Golgi lumen
- UDP-GalCHEBI:66914, C15H22N2O17P2, Golgi lumen
Outputs
- UDPCHEBI:58223, C9H11N2O12P2, Golgi lumen
- H+CHEBI:15378, H, Golgi lumen
- Gal-Gal-Xyl-proteinsR-HSA-2064214, Golgi lumen
Catalysed by
- galactosylxylosylprotein 3-beta-galactosyltransferase activity of B3GALT6 [Golgi membrane]EC 2.4.1.134; UniProt Q96L58
Literature
- Biosynthesis of the linkage region of glycosaminoglycans: cloning and activity of galactosyltransferase II, the sixth member of the beta 1,3-galactosyltransferase family (beta 3GalT6) J Biol Chem, 2001
- A beta-1,3-N-acetylglucosaminyltransferase with poly-N-acetyllactosamine synthase activity is structurally related to beta-1,3-galactosyltransferases Proc Natl Acad Sci U S A, 1999