XYLTs transfer Xyl to core protein
UDP-Xyl + GAG core proteins → UDP + xylosyl-core proteins + H+
- Reactome
- R-HSA-1878002
- Compartment
- Golgi membrane · Golgi lumen
- Rhea
- RHEA:50193
Inputs
- UDP-XylCHEBI:57632, C14H20N2O16P2, Golgi lumen
- GAG core proteinsR-HSA-2054107, Golgi lumen
Outputs
- UDPCHEBI:58223, C9H11N2O12P2, Golgi lumen
- xylosyl-core proteinsR-HSA-2064201, Golgi lumen
- H+CHEBI:15378, H, Golgi lumen
Catalysed by
- protein xylosyltransferase activity of XYLT1, XYLT2 [Golgi membrane]EC 2.4.2.26
Literature
- Analysis of the DXD motifs in human xylosyltransferase I required for enzyme activity J Biol Chem, 2004
- Human xylosyltransferase I: functional and biochemical characterization of cysteine residues required for enzymic activity Biochem J, 2005
- Molecular cloning and expression of human UDP-d-Xylose:proteoglycan core protein beta-d-xylosyltransferase and its first isoform XT-II J Mol Biol, 2000
- XT-II, the second isoform of human peptide-O-xylosyltransferase, displays enzymatic activity J. Biol. Chem., 2007