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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

GBA2 hydrolyzes GlcCer (plasma membrane)

GlcCer + H2O → CERA + Glc

Reactome: R-HSA-1861788
Compartment: plasma membrane · cytosol
Rhea: None recorded

Inputs

GlcCerCHEBI:22801, C25H46NO8R, plasma membrane
H2OCHEBI:15377, H2O, cytosol

Outputs

CERACHEBI:83273, C4H7NO3R2, plasma membrane
GlcCHEBI:4167, C6H12O6, cytosol

Catalysed by

glucosylceramidase activity of GBA2 [plasma membrane]EC 3.2.1.45; UniProt Q9HCG7

Literature

Molecular cloning and expression of human bile acid beta-glucosidase J Biol Chem, 2001
Identification of the non-lysosomal glucosylceramidase as beta-glucosidase 2 J Biol Chem, 2007