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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

Unknown endo-β-galactosidase cleaves keratan chain

H2O + KSPG(2) → KS core proteins + Gal(S)-GlcNAc(S)-Gal-GlcNAc(S)-Gal

Reactome: R-HSA-1793217
Compartment: lysosomal lumen
Rhea: None recorded

Inputs

H2OCHEBI:15377, H2O, lysosomal lumen
KSPG(2)R-HSA-2046191, lysosomal lumen

Outputs

KS core proteinsR-HSA-2105011, lysosomal lumen
Gal(S)-GlcNAc(S)-Gal-GlcNAc(S)-GalCHEBI:63846, C34H58N2O35S3, lysosomal lumen

Catalysed by

beta-galactosidase activity of keratan sulfate 1,4-beta-D-galactosidase [lysosomal lumen]EC 3.2.1.23

Literature

Human small-intestinal beta-galactosidases. Separation and characterization of one lactase and one hetero beta-galactosidase Biochem J, 1969