HYAL1-4 hydrolyze chondroitin chains
H2O + Chondroitin chains → CS/HS precursor
- Reactome
- R-HSA-1793209
- Compartment
- lysosomal lumen
- Rhea
- None recorded
Inputs
- H2OCHEBI:15377, H2O, lysosomal lumen
- Chondroitin chainsR-ALL-2065257, lysosomal lumen
Outputs
- CS/HS precursorCHEBI:747385, C23H37O21, lysosomal lumen
Catalysed by
- hyalurononglucosaminidase activity of HYAL1-like proteins [lysosomal lumen]EC 3.2.1.35
Literature
- Purification, cloning, and expression of human plasma hyaluronidase Biochem Biophys Res Commun, 1997
- Identification of human hyaluronidase-4 as a novel chondroitin sulfate hydrolase that preferentially cleaves the galactosaminidic linkage in the trisulfated tetrasaccharide sequence Glycobiology, 2010
- Mutations in HYAL1, a member of a tandemly distributed multigene family encoding disparate hyaluronidase activities, cause a newly described lysosomal disorder, mucopolysaccharidosis IX Proc. Natl. Acad. Sci. U.S.A., 1999