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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

Data

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

ARSB hydrolyses C4S/C6S chains

H2O + C4S/C6S chains → SO4(2-) + Chondroitin chain

Reactome: R-HSA-1793207
Compartment: lysosomal lumen
Rhea: None recorded

Inputs

H2OCHEBI:15377, H2O, lysosomal lumen
C4S/C6S chainsR-ALL-2065251, lysosomal lumen

Outputs

SO4(2-)CHEBI:16189, O4S, lysosomal lumen
Chondroitin chainCHEBI:747387, C45H70N2O37, lysosomal lumen

Catalysed by

N-acetylgalactosamine-4-sulfatase activity of ARSB:Ca2+ [lysosomal lumen]EC 3.1.6.12

Literature

Arylsulphatase B, an exo-sulphatase for chondroitin 4-sulphate tetrasaccharide Hoppe Seylers Z Physiol Chem, 1978
Crystal structure of a covalent intermediate of endogenous human arylsulfatase A J Inorg Biochem, 2003
Crystal structure of human arylsulfatase A: the aldehyde function and the metal ion at the active site suggest a novel mechanism for sulfate ester hydrolysis Biochemistry, 1998
A novel amino acid modification in sulfatases that is defective in multiple sulfatase deficiency Cell, 1995