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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

IDS hydrolyses dermatan sulfate (Chebi:63517 chain)

H2O + ChEBI:63517 chain → SO4(2-) + ChEBI:63516 chain

Reactome: R-HSA-1793182
Compartment: lysosomal lumen
Rhea: None recorded

Inputs

H2OCHEBI:15377, H2O, lysosomal lumen
ChEBI:63517 chainCHEBI:747397, C45H68N2O43S2, lysosomal lumen

Outputs

SO4(2-)CHEBI:16189, O4S, lysosomal lumen
ChEBI:63516 chainCHEBI:747395, C45H69N2O40S, lysosomal lumen

Catalysed by

iduronate-2-sulfatase activity of IDS dimer [lysosomal lumen]EC 3.1.6.13

Literature

Hunter syndrome: isolation of an iduronate-2-sulfatase cDNA clone and analysis of patient DNA Proc Natl Acad Sci U S A, 1990