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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

DS is cleaved from its proteoglycan

H2O + D2,4,4(S)3-PGs → CS/DS core proteins + ChEBI:63519 chain

Reactome: R-HSA-1793176
Compartment: lysosomal lumen
Rhea: None recorded

Inputs

H2OCHEBI:15377, H2O, lysosomal lumen
D2,4,4(S)3-PGsR-HSA-2065138, lysosomal lumen

Outputs

CS/DS core proteinsR-HSA-2065248, lysosomal lumen
ChEBI:63519 chainCHEBI:747399, C45H68N2O46S3, lysosomal lumen

Catalysed by

hydrolase activity, acting on glycosyl bonds of beta-xylosidase [lysosomal lumen]EC 3.2

Literature

Demonstration of an endo-beta-galactosidase and an endo-beta-xylosidase that degrade the proteoglycan linkage region Biochim Biophys Acta, 1988