Loading the map…

Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

PAPSS1,2 transfer SO4(2-) group to ATP to form APS

ATP + SO4(2-) + H+ → APS + PPi

Reactome: R-HSA-174392
Compartment: cytosol
Rhea: RHEA:18134

Inputs

ATPCHEBI:30616, C10H12N5O13P3, cytosol
SO4(2-)CHEBI:16189, O4S, cytosol
H+CHEBI:15378, H, cytosol

Outputs

APSCHEBI:58243, C10H12N5O10PS, cytosol
PPiCHEBI:33019, HO7P2, cytosol

Catalysed by

sulfate adenylyltransferase (ATP) activity of PAPSS1,2 [cytosol]EC 2.7.7.4

PAPSS1,2 transfer SO4(2-) group to ATP to form APS

Inputs

Outputs

Catalysed by

Literature