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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS

ATP + APS → ADP + PAPS + H+

Reactome: R-HSA-174389
Compartment: cytosol
Rhea: RHEA:24153

Inputs

ATPCHEBI:30616, C10H12N5O13P3, cytosol
APSCHEBI:58243, C10H12N5O10PS, cytosol

Outputs

ADPCHEBI:456216, C10H12N5O10P2, cytosol
PAPSCHEBI:58339, C10H11N5O13P2S, cytosol
H+CHEBI:15378, H, cytosol

Catalysed by

adenylylsulfate kinase activity of PAPSS1,2 [cytosol]EC 2.7.1.25

PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS

Inputs

Outputs

Catalysed by

Literature