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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

NAGLU hydrolyses Heparan sulfate chain(4)

GlcNAc-IdoA2S-GlcNS3S- group + H2O → GlcNAc + IdoA2S-GlcNS3S- group

Reactome: R-HSA-1678742
Compartment: lysosomal lumen
Rhea: None recorded

Inputs

GlcNAc-IdoA2S-GlcNS3S- groupCHEBI:63807, C43H69N2O44S3, lysosomal lumen
H2OCHEBI:15377, H2O, lysosomal lumen

Outputs

GlcNAcCHEBI:17411, C8H15NO6, lysosomal lumen
IdoA2S-GlcNS3S- groupCHEBI:63808, C35H56NO39S3, lysosomal lumen

Catalysed by

alpha-N-acetylglucosaminidase activity of NAGLU(59-743) [lysosomal lumen]EC 3.2.1.50; UniProt P54802

Literature

Cloning and expression of the gene involved in Sanfilippo B syndrome (mucopolysaccharidosis III B) Hum Mol Genet, 1996
Molecular defects in Sanfilippo syndrome type B (mucopolysaccharidosis IIIB) J Inherit Metab Dis, 2005