Heparanase 2 (HPSE2) binds heparan sulfate proteoglycans
HS/HPIN-PGs + HPSE2(1-592) → HPSE2:HS/HPIN-PGs
- Reactome
- R-HSA-1678694
- Compartment
- plasma membrane · extracellular region
- Rhea
- None recorded
Inputs
- HS/HPIN-PGsR-HSA-2076639, plasma membrane
- HPSE2(1-592)R-HSA-1678680, plasma membrane
Outputs
- HPSE2:HS/HPIN-PGsR-HSA-9774311, plasma membrane
Catalysed by
- protein sequestering activity of HPSE2(1-592) [plasma membrane]UniProt Q8WWQ2
Literature
- Mutations in HPSE2 cause urofacial syndrome Am J Hum Genet, 2010
- Heparanase 2 interacts with heparan sulfate with high affinity and inhibits heparanase activity J Biol Chem, 2010
- Cloning and expression profiling of Hpa2, a novel mammalian heparanase family member Biochem Biophys Res Commun, 2000
- Loss-of-function mutations in HPSE2 cause the autosomal recessive urofacial syndrome Am J Hum Genet, 2010