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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

IDS hydrolyses Heparan sulfate chain(5)

H2O + IdoA2S-GlcNS3S- group → SO4(2-) + IdoA-GlcNS3S- group

Reactome: R-HSA-1678650
Compartment: lysosomal lumen
Rhea: None recorded

Inputs

H2OCHEBI:15377, H2O, lysosomal lumen
IdoA2S-GlcNS3S- groupCHEBI:63808, C35H56NO39S3, lysosomal lumen

Outputs

SO4(2-)CHEBI:16189, O4S, lysosomal lumen
IdoA-GlcNS3S- groupCHEBI:63809, C35H56NO36S2, lysosomal lumen

Catalysed by

iduronate-2-sulfatase activity of IDS dimer [lysosomal lumen]EC 3.1.6.13

Literature

Hunter syndrome: isolation of an iduronate-2-sulfatase cDNA clone and analysis of patient DNA Proc Natl Acad Sci U S A, 1990