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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

ADP and Pi bind to ATPase

ADP + Pi + F1Fo ATP synthase → ATPase:ADP:Pi

Reactome: R-HSA-164840
Compartment: mitochondrial matrix · mitochondrial inner membrane
Rhea: RHEA:57722

Inputs

ADPCHEBI:456216, C10H12N5O10P2, mitochondrial matrix
PiCHEBI:43474, HO4P, mitochondrial matrix
F1Fo ATP synthaseR-HSA-74186, mitochondrial inner membrane

Outputs

ATPase:ADP:PiR-HSA-164838, mitochondrial inner membrane

Literature

A new concept for energy coupling in oxidative phosphorylation based on a Proc Natl Acad Sci U S A, 1973