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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

Enzyme-bound ATP is released

ATPase:ATP + 3 H+ → F1Fo ATP synthase + ATP + 3 H+

Reactome: R-HSA-164834
Compartment: mitochondrial matrix
Rhea: RHEA:57722

Inputs

ATPase:ATPR-HSA-164835, mitochondrial inner membrane
3 H+CHEBI:15378, H, mitochondrial intermembrane space

Outputs

F1Fo ATP synthaseR-HSA-74186, mitochondrial inner membrane
ATPCHEBI:30616, C10H12N5O13P3, mitochondrial matrix
3 H+CHEBI:15378, H, mitochondrial matrix

Catalysed by

proton transmembrane transporter activity of ATPase:ATP [mitochondrial inner membrane]

Literature

A new concept for energy coupling in oxidative phosphorylation based on a Proc Natl Acad Sci U S A, 1973