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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

CERK phosphorylates CERA to form C1P

ATP + CERA → ADP + C1P + H+

Reactome: R-HSA-1638845
Compartment: plasma membrane · cytosol
Rhea: None recorded

Inputs

ATPCHEBI:30616, C10H12N5O13P3, cytosol
CERACHEBI:83273, C4H7NO3R2, plasma membrane

Outputs

ADPCHEBI:456216, C10H12N5O10P2, cytosol
C1PCHEBI:16197, C19H37NO6PR, plasma membrane
H+CHEBI:15378, H, cytosol

Catalysed by

ceramide kinase activity of CERK [plasma membrane]EC 2.7.1.138; UniProt Q8TCT0

Literature

Ceramide kinase, a novel lipid kinase. Molecular cloning and functional characterization J Biol Chem, 2002
Ceramide kinase: the first decade Cell Signal, 2011
The Role of Sphingosine-1-Phosphate and Ceramide-1-Phosphate in Inflammation and Cancer Mediators Inflamm, 2017