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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

UGCG transfers glucose to ceramide

UDP-Glc + CERA-d18 → GlcCer + UDP + H+

Reactome: R-HSA-1638104
Compartment: Golgi membrane · Golgi lumen
Rhea: RHEA:12088

Inputs

UDP-GlcCHEBI:58885, C15H22N2O17P2, Golgi lumen
CERA-d18CHEBI:52639, C19H36NO3R, Golgi membrane

Outputs

GlcCerCHEBI:22801, C25H46NO8R, Golgi membrane
UDPCHEBI:58223, C9H11N2O12P2, Golgi lumen
H+CHEBI:15378, H, Golgi lumen

Catalysed by

ceramide glucosyltransferase activity of UGCG [Golgi membrane]EC 2.4.1.80; UniProt Q16739

Literature

Expression cloning of a cDNA for human ceramide glucosyltransferase that catalyzes the first glycosylation step of glycosphingolipid synthesis Proc Natl Acad Sci U S A, 1996
The reconstituted P-glycoprotein multidrug transporter is a flippase for glucosylceramide and other simple glycosphingolipids Biochem J, 2005
Role of multiple drug resistance protein 1 in neutral but not acidic glycosphingolipid biosynthesis J Biol Chem, 2004
Ceramide glycosylation catalyzed by glucosylceramide synthase and cancer drug resistance Adv. Cancer Res., 2013