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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

HEXA cleaves the terminal GlcNAc from keratan sulfate

H2O + GlcNAc-Gal-GlcNAc(S)-Gal → Gal-GlcNAc(S)-Gal + GlcNAc

Reactome: R-HSA-1638053
Compartment: lysosomal lumen
Rhea: None recorded

Inputs

H2OCHEBI:15377, H2O, lysosomal lumen
GlcNAc-Gal-GlcNAc(S)-GalCHEBI:63852, C28H48N2O24S, lysosomal lumen

Outputs

Gal-GlcNAc(S)-GalCHEBI:63853, C20H35NO19S, lysosomal lumen
GlcNAcCHEBI:17411, C8H15NO6, lysosomal lumen

Catalysed by

beta-N-acetylhexosaminidase activity of bHEXA [lysosomal lumen]EC 3.2.1.52

Literature

Oligosaccharide structure and amino acid sequence of the major glycopeptides of mature human beta-hexosaminidase Biochemistry, 1988