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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

GLB1 hydrolyses a glycosaminoglycan

H2O + Gal-GlcNAc(S)-Gal-GlcNAc(S)-Gal → Gal + GlcNAc(S)-Gal-GlcNAc(S)-Gal

Reactome: R-HSA-1630306
Compartment: lysosomal lumen
Rhea: None recorded

Inputs

H2OCHEBI:15377, H2O, lysosomal lumen
Gal-GlcNAc(S)-Gal-GlcNAc(S)-GalCHEBI:63850, C34H58N2O31S2, lysosomal lumen

Outputs

GalCHEBI:28061, C6H12O6, lysosomal lumen
GlcNAc(S)-Gal-GlcNAc(S)-GalCHEBI:63851, C28H48N2O27S2, lysosomal lumen

Catalysed by

beta-galactosidase activity of BGAL [lysosomal lumen]EC 3.2.1.23

Literature

Human small-intestinal beta-galactosidases. Separation and characterization of one lactase and one hetero beta-galactosidase Biochem J, 1969
Human beta-galactosidase gene mutations in GM1-gangliosidosis: a common mutation among Japanese adult/chronic cases Am J Hum Genet, 1991
Human beta-galactosidase gene mutations in morquio B disease Am J Hum Genet, 1991