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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

ASAH2 hydrolyzes ceramide (plasma membrane)

CERA + H2O → SPG + RCOO-

Reactome: R-HSA-1606583
Compartment: plasma membrane · cytosol
Rhea: RHEA:78455

Inputs

CERACHEBI:83273, C4H7NO3R2, plasma membrane
H2OCHEBI:15377, H2O, cytosol

Outputs

SPGCHEBI:84410, C3H9NO2R, plasma membrane
RCOO-CHEBI:28868, CO2R, cytosol

Catalysed by

N-acylsphingosine amidohydrolase activity of ASAH2-like proteins [plasma membrane]EC 3.5.1.23

Literature

Subcellular localization of human neutral ceramidase expressed in HEK293 cells Biochem Biophys Res Commun, 2005
Identification of a novel amidase motif in neutral ceramidase Biochem J, 2006