GLB1 hydrolyzes SapB/C:LacCer
H2O + Sap B/C:LacCer → Gal + Sap B/C:GlcCer
- Reactome
- R-HSA-1606312
- Compartment
- lysosomal lumen
- Rhea
- None recorded
Inputs
- H2OCHEBI:15377, H2O, lysosomal lumen
- Sap B/C:LacCerR-HSA-9840969, lysosomal lumen
Outputs
- GalCHEBI:28061, C6H12O6, lysosomal lumen
- Sap B/C:GlcCerR-HSA-9840964, lysosomal lumen
Catalysed by
- beta-galactosidase activity of BGAL [lysosomal lumen]EC 3.2.1.23
Literature
- Human small-intestinal beta-galactosidases. Separation and characterization of one lactase and one hetero beta-galactosidase Biochem J, 1969
- Emerging concepts of ganglioside metabolism FEBS Lett, 2018
- Prosaposin deficiency: further characterization of the sphingolipid activator protein-deficient sibs. Multiple glycolipid elevations (including lactosylceramidosis), partial enzyme deficiencies and ultrastructure of the skin in this generalized sphingolipid storage disease Hum Genet, 1993