Loading the map…

Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

SMPD4 hydrolyzes sphingomyelin (ER membrane)

SPHM d18:1 + H2O → CERA + ChoP + H+

Reactome: R-HSA-1606288
Compartment: endoplasmic reticulum lumen · endoplasmic reticulum membrane
Rhea: None recorded

Inputs

SPHM d18:1CHEBI:17636, C24H48N2O6PR, endoplasmic reticulum membrane
H2OCHEBI:15377, H2O, endoplasmic reticulum lumen

Outputs

CERACHEBI:83273, C4H7NO3R2, endoplasmic reticulum membrane
ChoPCHEBI:18132, C5H15NO4P, endoplasmic reticulum lumen
H+CHEBI:15378, H, cytosol

Catalysed by

sphingomyelin phosphodiesterase activity of SMPD4:Mg2+ [endoplasmic reticulum membrane]EC 3.1.4.12

Literature

Novel tumor necrosis factor-responsive mammalian neutral sphingomyelinase-3 is a C-tail-anchored protein J Biol Chem, 2006
Loss of SMPD4 Causes a Developmental Disorder Characterized by Microcephaly and Congenital Arthrogryposis Am J Hum Genet, 2019