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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane)

SPHM d18:1 + H2O → CERA + ChoP + H+

Reactome: R-HSA-1606273
Compartment: plasma membrane · cytosol
Rhea: None recorded

Inputs

SPHM d18:1CHEBI:17636, C24H48N2O6PR, plasma membrane
H2OCHEBI:15377, H2O, cytosol

Outputs

CERACHEBI:83273, C4H7NO3R2, plasma membrane
ChoPCHEBI:295975, C5H13NO4P, plasma membrane
H+CHEBI:15378, H, cytosol

Catalysed by

sphingomyelin phosphodiesterase activity of SMPD2,3:Mg2+ [plasma membrane]EC 3.1.4.12

Literature

Cloned mammalian neutral sphingomyelinase: functions in sphingolipid signaling? Proc Natl Acad Sci U S A, 1998
Cloning and characterization of the mammalian brain-specific, Mg2+-dependent neutral sphingomyelinase Proc Natl Acad Sci U S A, 2000
Biochemical properties of mammalian neutral sphingomyelinase 2 and its role in sphingolipid metabolism J Biol Chem, 2003