GM2A binds and mobilizes ligands
GM2A(32-193) + GM2A ligands → GM2A:Ligands
- Reactome
- R-HSA-1605717
- Compartment
- lysosomal lumen · multivesicular body, internal vesicle membrane
- Rhea
- None recorded
Inputs
- GM2A(32-193)R-HSA-1605614, lysosomal lumen
- GM2A ligandsR-ALL-9840941, multivesicular body, internal vesicle membrane
Outputs
- GM2A:LigandsR-HSA-9840631, lysosomal lumen
Catalysed by
- sphingolipid activator protein activity of GM2A(32-193) [lysosomal lumen]UniProt P17900
Literature
- Structural analysis of lipid complexes of GM2-activator protein J Mol Biol, 2003
- A mutation in the gene of a glycolipid-binding protein (GM2 activator) that causes GM2-gangliosidosis variant AB FEBS Lett, 1991
- Degradation of membrane-bound ganglioside GM1. Stimulation by bis(monoacylglycero)phosphate and the activator proteins SAP-B and GM2-AP J Biol Chem, 2000
- Emerging concepts of ganglioside metabolism FEBS Lett, 2018