Skip to content

DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

Data

Loading the map…

Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

Beta-galactosidases hydrolyse mobilized GM1 to mobilized GM2

H2O + mobilized GM1 → Gal + mobilized GM2

Reactome: R-HSA-1605624
Compartment: lysosomal lumen · lysosomal membrane
Rhea: None recorded

Inputs

H2OCHEBI:15377, H2O, lysosomal lumen
mobilized GM1R-HSA-9840644, lysosomal lumen

Outputs

GalCHEBI:28061, C6H12O6, lysosomal lumen
mobilized GM2R-HSA-9840646, lysosomal lumen

Catalysed by

beta-galactosidase activity of BGAL [lysosomal lumen]EC 3.2.1.23

Literature

Human small-intestinal beta-galactosidases. Separation and characterization of one lactase and one hetero beta-galactosidase Biochem J, 1969
Human beta-galactosidase gene mutations in GM1-gangliosidosis: a common mutation among Japanese adult/chronic cases Am J Hum Genet, 1991
Degradation of membrane-bound ganglioside GM1. Stimulation by bis(monoacylglycero)phosphate and the activator proteins SAP-B and GM2-AP J Biol Chem, 2000
GM1 gangliosidosis: review of clinical, molecular, and therapeutic aspects Mol Genet Metab, 2008