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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

GBA1:SAPC hydrolyzes GlcCer

GlcCer + H2O → CERA + Glc

Reactome: R-HSA-1605591
Compartment: lysosomal membrane · lysosomal lumen
Rhea: None recorded

Inputs

GlcCerCHEBI:22801, C25H46NO8R, lysosomal lumen
H2OCHEBI:15377, H2O, lysosomal lumen

Outputs

CERACHEBI:83273, C4H7NO3R2, lysosomal lumen
GlcCHEBI:4167, C6H12O6, lysosomal lumen

Catalysed by

glucosylceramidase activity of GBA1:SAPC [lysosomal membrane]EC 3.2.1.45

Literature

Human acid beta-glucosidase: isolation and amino acid sequence of a peptide containing the catalytic site Proc Natl Acad Sci U S A, 1986
Further studies on the reconstitution of glucosylceramidase activity by Sap C and anionic phospholipids FEBS Lett, 2000
Glucocerebrosidase (Gaucher disease) Hum Mutat, 1996
Lipids regulate the hydrolysis of membrane bound glucosylceramide by lysosomal β-glucocerebrosidase J Lipid Res, 2017