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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

Sepiapterin reductase (SPR) is phosphorylated by Ca2+/calmodulin-dependent protein kinase II

SPR dimer + 2 ATP → 2 ADP + p-SPR dimer

Reactome: R-HSA-1497853
Compartment: cytosol
Rhea: None recorded

Inputs

SPR dimerR-HSA-1497791, cytosol
2 ATPCHEBI:30616, C10H12N5O13P3, cytosol

Outputs

2 ADPCHEBI:456216, C10H12N5O10P2, cytosol
p-SPR dimerR-HSA-1497817, cytosol

Catalysed by

cGMP-dependent protein kinase activity of PRKG2 [cytosol]EC 2.7.11.12; UniProt Q13237

Sepiapterin reductase (SPR) is phosphorylated by Ca2+/calmodulin-dependent protein kinase II

Inputs

Outputs

Catalysed by

Literature